Intestinal Permeability Urine Test Kit

Name: Intestinal Permeability Urine Test Kit
Brand: Nutripath
Price: 178.0 AUD
Availability: InStock

$178.00 AUD

Dealing with persistent digestive symptoms, food sensitivities or inflammation and want to know whether your gut barrier function could be a factor?

At-home lactulose-mannitol challenge test measuring gut barrier function through timed urine collection. High lactulose recovery indicates increased intestinal permeability. Provides an objective measure of gut barrier integrity for practitioner review.

Your at-home test kit and all instructions are posted directly to you (with free shipping). You do not need to visit a collection centre.

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Private health tests

How At-Home Testing Works

Get tested from the comfort of your home with our simple three-step process.

Order your test kit

Choose the test that's right for you and receive your kit delivered to your door.

Collect your sample

Follow the simple instructions to collect your sample at home.

Get your results

Receive your results online and get personalised health insights.

Overview

Your intestinal lining acts as a selective barrier, allowing nutrients to pass into the bloodstream while keeping larger molecules, bacteria, and toxins out. When this barrier becomes more permeable than it should be, molecules that would normally be blocked can cross into the bloodstream and trigger immune and inflammatory responses. This increased permeability is sometimes referred to as leaky gut.

The lactulose-mannitol challenge test is a well-established method for measuring intestinal permeability. Mannitol is a small sugar molecule that passes easily through a healthy gut lining. Lactulose is larger and should not cross easily under normal conditions. After drinking a solution containing both sugars, you collect your urine over a timed period. The ratio of lactulose to mannitol recovered in the urine indicates how permeable your gut lining currently is.

Increased intestinal permeability has been associated with a range of conditions, including inflammatory bowel disease, coeliac disease, food sensitivities, chronic stress, and the use of certain medications such as NSAIDs. It is also a topic of growing research in relation to autoimmune conditions, though the evidence for a direct causal link is still developing.

This test provides an objective, measurable assessment of gut barrier function rather than relying on symptom-based assumptions. Your practitioner can use the results alongside your clinical history to decide whether gut barrier support should be part of your overall management plan. Follow-up testing can also track whether the barrier is improving over time in response to interventions.

Symptoms

Suited to people investigating gut barrier function as a possible factor in digestive symptoms, food sensitivities or inflammatory conditions.

Questions

Your intestinal lining controls what passes into your bloodstream. Increased permeability means larger molecules can get through, potentially triggering immune and inflammatory responses.
Mannitol is a small sugar that passes through healthy gut lining. Lactulose is larger and should not pass easily. High lactulose recovery indicates increased permeability.
NSAIDs, alcohol, stress, infections, dysbiosis, inflammatory bowel disease, coeliac disease and various other factors can compromise gut barrier function.
Often yes. Removing triggers, supporting gut healing with targeted nutrients, and addressing underlying conditions frequently improves permeability over time.
It varies by severity and underlying causes. Many people see improvement within 4 to 12 weeks of appropriate intervention, though some cases take longer.
Intestinal permeability is a measurable phenomenon accepted in gastroenterology. The broader concept of leaky gut syndrome as a cause of widespread symptoms remains more debated.

Dr. Vu Tran
Bloody Good’s Chief Medical Officer

How to prepare

Fast for 12 hours before testing (water is fine). Avoid NSAIDs, alcohol and certain medications for 48 hours beforehand. Drink the provided test solution, then collect urine samples at the times specified in your kit instructions. Avoid strenuous exercise during the collection period.

After the test

Discuss results with your practitioner. If increased permeability is confirmed, they may recommend dietary changes, specific nutrients that support gut lining repair, and strategies to address underlying causes such as food triggers or chronic stress. Follow-up testing can track whether the barrier is improving over time.

Your test results will be available in your private dashboard. If there are any urgent issues, we'll let you know so you can follow up with your health professional.

Understanding results

Your report shows lactulose recovery, mannitol recovery and the lactulose-to-mannitol ratio. An elevated ratio suggests increased intestinal permeability, meaning the gut barrier is letting through molecules that it normally would not. Low mannitol recovery on its own may point to reduced absorption. Your practitioner can interpret these results in the context of your symptoms and health history.

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