Lactate Dehydrogenase Isoenzymes Blood Test

Over 250k Biomarkers Tested

Lactate Dehydrogenase Isoenzymes Blood Test

$58.00 AUD

Previously elevated total LDH and need to identify which organ or tissue is the source?

Separates LDH into five isoenzymes that identify which organ is releasing elevated LDH. LDH-1/2 suggest heart or blood cells, LDH-3 lung tissue, LDH-4 kidney/pancreas, LDH-5 liver or skeletal muscle.
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You will be emailed a referral to take to your local collection centre. If you ever have any questions, we're here to help.

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1
Order a test

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Order the private test that suits you and your goals. After ordering, you will receive your referral by email.

2
Collect the sample

Collect the sample

Attend one of our 4000+ partner collection centres throughout Australia. Search locations.

3
Receive your results

Receive your results

View all your lab results in your secure health dashboard. Easy!

Overview

LDH Isoenzymes testing separates total LDH into five fractions, each predominant in different tissues. This pattern identification helps determine which organ is releasing elevated LDH into the bloodstream.

LDH-1 and LDH-2 predominate in heart muscle and red blood cells. LDH-3 is found in lung and lymph tissue. LDH-4 in kidney and pancreas. LDH-5 in liver and skeletal muscle. The pattern of elevation points toward the affected organ, available across Australia.

This test is useful when total LDH is elevated but the clinical picture doesn't clearly identify the source. It helps focus further investigation on the appropriate organ system.

Symptoms

Essential for people with unexplained LDH elevation needing to identify the tissue source.

Questions

  • When total LDH is elevated but the source is unclear. Isoenzyme patterns identify whether elevation comes from heart, liver, muscle, blood cells, or other tissues.
  • Normally LDH-2 exceeds LDH-1. When LDH-1 exceeds LDH-2, it suggests heart muscle damage or hemolysis (red blood cell destruction). This pattern was historically used for heart attack diagnosis.
  • Yes. Heart damage elevates LDH-1 and LDH-2. Liver damage elevates LDH-5. Different patterns help identify the affected organ.
  • Some medications cause specific organ damage that affects particular isoenzymes. Inform your healthcare provider of all medications.
  • Isoenzymes rise within hours of tissue damage, peak at 24-48 hours, and return to normal as tissue heals (timing varies by organ).
  • Less common now that more specific markers exist (troponin for heart, specific liver enzymes). Still useful when the source of LDH elevation is unclear.

Dr. Vu Tran
Bloody Good’s Chief Medical Officer

2 Biomarkers Tested

How to prepare

No special preparation required. Avoid strenuous exercise 24 hours before testing as it can elevate muscle-related isoenzymes. Inform healthcare provider of all medications and recent medical procedures.

After the test

Address underlying organ damage based on isoenzyme pattern results through targeted diagnostic workup, appropriate treatments for affected organs, and monitoring of tissue recovery. Work with specialists based on identified organ involvement.

Your test results will be available in your private dashboard. If there are any urgent issues, we'll let you know so you can follow up with your health professional.

Understanding results

Results show the pattern and levels of each LDH isoenzyme, helping identify which organs or tissues are damaged. Specific patterns indicate heart, liver, muscle, lung, or other tissue involvement.

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Frequently Asked Questions

Most collection centres accept walk-ins. Some may require a booking - check details when you click on your chosen location.

If your test needs fasting, we’ll include that in your instructions after you order. Fasting usually means no food for 8–12 hours, but water is fine.

Just your pathology referral form (we email it to you)

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