Hormone & Endocrine - Bloody Good
Hormone

Testosterone (LCMS)

Want a clear picture of your hormone balance? Testosterone is vital for energy, muscle mass, libido, and overall health in both men and women. This LCMS test gives highly accurate results and may help assess fertility, sexual health, and hormone-related symptoms. For men on testosterone or performance therapies, LCMS testing is especially important, as it provides reliable readings even when testosterone levels are higher than normal.  (not available in NT)

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Need the most accurate testosterone measurement possible for confident diagnosis, especially if previous results were borderline, inconsistent, or you're taking medications that might interfere with standard testing?

Overview

Think of LCMS testosterone testing as having a molecular detective with a perfect track record – it can precisely identify and measure your testosterone levels without getting confused by other similar hormones or medications that might throw off regular tests. While standard testosterone tests are convenient and widely used, they sometimes mistake other substances for testosterone or get interference from supplements and medications, potentially giving you inaccurate results that could lead to the wrong treatment decisions.

This advanced testing method works like a two-step verification system: first, it separates testosterone from everything else in your blood sample, then it confirms the identity using molecular fingerprinting technology. This gold-standard accuracy becomes especially important when your testosterone levels are borderline, when you're monitoring hormone therapy, or when previous test results didn't match how you're feeling. LCMS testing is particularly valuable for women (who naturally have much lower testosterone levels where precision matters most), anyone taking medications that might interfere with standard tests, or when you need rock-solid accuracy for legal or athletic purposes – ensuring your treatment decisions are based on the most reliable measurements possible.

Reviewed by Dr. Vu Tran
Bloody Good’s Chief Medical Officer

Symptoms

You may benefit from this test if you experience:

Low sex drive in men Erectile dysfunction Loss of muscle mass in men Increased body fat around waist (men) Decreased morning erections Infertility in men Feeling tired all the time Feeling sad or down most of the time

Purpose

Essential for women requiring precise testosterone measurement, individuals with borderline results needing confirmation, those taking interfering medications, monitoring hormone replacement therapy, research purposes, or when maximum accuracy is required for treatment decisions.

How to prepare

Morning collection (7-10 AM) critical for accurate assessment. No fasting required. Avoid biotin supplements for 3 days before testing. List all medications and supplements as some may require special consideration for LCMS analysis. Inform laboratory of any previous inconsistent results or suspected interference issues.

Understanding results

Reference ranges identical to standard testosterone but with superior accuracy: Men: Age-adjusted ranges 9-25 nmol/L; Women: 0.7-2.8 nmol/L. LCMS results are considered definitive and used to resolve discrepancies from immunoassay testing. Results provide confidence for treatment decisions due to superior analytical specificity.

After the test

Use LCMS results as definitive assessment for hormone replacement therapy decisions. If results differ significantly from previous immunoassay testing, consider LCMS as more accurate. Proceed with treatment decisions based on LCMS values combined with clinical symptoms. Regular LCMS monitoring recommended for hormone replacement therapy optimization.

Frequently Asked Questions

  • LCMS physically separates and identifies testosterone molecules, eliminating cross-reactivity with similar hormones that can interfere with immunoassay methods, providing true testosterone-specific results.
  • Choose LCMS for borderline results, women's testing, medication interference concerns, monitoring hormone therapy, research purposes, or when maximum accuracy is essential for treatment decisions.
  • Yes, LCMS typically costs more than immunoassay testing, but the superior accuracy often justifies the expense, especially for critical diagnostic or monitoring situations.
  • LCMS is considered the reference method with accuracy within 2-3%, compared to immunoassays which can have 10-20% variability due to cross-reactivity and interference issues.
  • Yes, LCMS has superior sensitivity and specificity at low concentrations, making it particularly valuable for women's testing and detecting subtle deficiencies in men.
  • Preparation is similar to standard testosterone testing, but inform your provider about all medications and supplements as some may require specific timing considerations for optimal accuracy.

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How it works

What to expect

We want you to feel bloody good—inside and out. Regular testing isn’t just about checking your current health; it helps you spot abnormal values you might not know about.

1

Book your referral

Choose the testing that suits your goals. After ordering, you will receive your referral by email.

2

Collect your sample

Easy sample collection at one of our 4000+ partner collection centres throughout Australia. Find nearest

3
Receive your results

Receive your results

View your lab results and receive a personalised review from the secure Bloody Good platform.

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