Hydroxyprogesterone Blood Test
Hydroxyprogesterone Blood Test
Woman in medical attire with a stethoscope on a pink background, featuring text about a medical team being ready to help.
Hydroxyprogesterone Blood Test
Hydroxyprogesterone Blood Test
Hydroxyprogesterone Blood Test
Hydroxyprogesterone Blood Test
Hydroxyprogesterone Blood Test
Woman in medical attire with a stethoscope on a pink background, featuring text about a medical team being ready to help.
Hydroxyprogesterone Blood Test
Hydroxyprogesterone Blood Test
Hydroxyprogesterone Blood Test

Over 250k Biomarkers Tested

Hydroxyprogesterone Blood Test

$58.00 AUD

Have your testosterone and DHEAS results suggested androgen excess but the cause is unclear?

Measures 17-hydroxyprogesterone (17-OHP), a steroid in the cortisol synthesis pathway. Elevated levels indicate an adrenal enzyme deficiency, most commonly 21-hydroxylase deficiency (congenital adrenal hyperplasia). Used to screen for CAH and investigate unexplained androgen excess.

Collection Location
Specimen Type

You will be emailed a referral to take to your local collection centre. If you ever have any questions, we're here to help.

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How It Works

Getting your health measured shouldn't be hard! We're here to help you every step of the way.

1
Order a test

Order a test

Order the private test that suits you and your goals. After ordering, you will receive your referral by email.

2
Collect the sample

Collect the sample

Attend one of our 4000+ partner collection centres throughout Australia. Search locations.

3
Receive your results

Receive your results

View all your lab results in your secure health dashboard. Easy!

Overview

17-Hydroxyprogesterone (17-OHP) is a steroid hormone produced primarily in the adrenal glands as an intermediate step in the production of cortisol. Under normal circumstances, 17-OHP is efficiently converted to cortisol by the enzyme 21-hydroxylase. When this enzyme is deficient, 17-OHP accumulates and is redirected into androgen (male hormone) production instead. This enzymatic bottleneck is the basis of congenital adrenal hyperplasia (CAH), the most common adrenal disorder.

CAH exists on a spectrum. Classical CAH is severe, detected at birth or in early childhood through newborn screening, and can cause ambiguous genitalia in females and salt-wasting crises in both sexes if untreated. Non-classical (late-onset) CAH is milder and often goes unrecognised until adolescence or adulthood, when it may present with hirsutism, acne, irregular periods, and fertility difficulties. These symptoms overlap substantially with polycystic ovary syndrome (PCOS), which is why 17-OHP testing is recommended by many endocrine guidelines before confirming a PCOS assessment.

A basal 17-OHP drawn in the early follicular phase of the menstrual cycle (days 1 to 5) is the standard screening approach for women. If the basal level is clearly normal, classical and most non-classical CAH due to 21-hydroxylase deficiency can be effectively excluded. Borderline or elevated results typically lead to ACTH stimulation testing, where 17-OHP is measured before and 60 minutes after an injection of synthetic ACTH. An exaggerated response confirms the enzyme deficiency.

For people already diagnosed with CAH, 17-OHP is monitored regularly to assess whether corticosteroid replacement therapy is adequately suppressing excess androgen production. The goal is to keep 17-OHP within a target range that balances effective treatment with avoiding over-replacement.

Symptoms

Essential for people being screened for CAH, those with symptoms of androgen excess, women with fertility issues, or anyone with family history of adrenal enzyme deficiencies.

Questions

  • Congenital adrenal hyperplasia is a group of inherited adrenal disorders caused by deficiencies in enzymes needed to produce cortisol. The most common cause is 21-hydroxylase deficiency, which causes 17-OHP to accumulate and be redirected into excess androgen production. Classical CAH is severe and detected at birth or in early childhood. Non-classical CAH is milder, often presents in adolescence or adulthood, and can mimic PCOS with symptoms of androgen excess.
  • Non-classical CAH caused by 21-hydroxylase deficiency can look virtually identical to PCOS, with symptoms including hirsutism, acne, irregular periods, and fertility difficulties. Because the treatment differs, it is important to distinguish the two. Testing 17-OHP, particularly in women with a family background where CAH is more common, is recommended before diagnosing PCOS in guidelines from many endocrine societies.
  • 17-OHP rises naturally in the luteal phase (second half) of the menstrual cycle, which can make results harder to interpret. For a baseline screen, early follicular phase collection (days 1 to 5 of the cycle) in the morning is preferred. If you are not menstruating or are post-menopausal, morning collection applies without cycle timing concerns.
  • A mildly or borderline elevated result on a basal test is not conclusive for CAH. The standard next step is an ACTH (cosyntropin) stimulation test, where 17-OHP is measured before and 60 minutes after a dose of synthetic ACTH. An exaggerated rise in 17-OHP after ACTH is consistent with a diagnosis of non-classical CAH. Your practitioner will arrange this test if indicated.
  • Yes. Progesterone and 17-hydroxyprogesterone are related but distinct steroids. Progesterone is the primary hormone of the luteal phase and is used to confirm ovulation. 17-OHP is a metabolite in the cortisol production pathway in the adrenal glands, and elevated levels specifically indicate a blockage in that pathway. They are tested for very different clinical purposes.
  • In people with CAH on corticosteroid replacement therapy, 17-OHP levels reflect how well the treatment is suppressing excess adrenal androgen production. Under-treated CAH results in persistently elevated 17-OHP and continued androgen excess. Over-treatment with steroids carries its own risks. Regular 17-OHP monitoring allows dose adjustment to keep levels within the therapeutic target range.

Dr. Vu Tran
Bloody Good’s Chief Medical Officer

No biomarkers found for this product.

How to prepare

No fasting is required for most clinical purposes. Eat and drink normally beforehand.

For women, morning collection in the early follicular phase (day 1 to 5 of the cycle) produces the most interpretable result, as 17-OHP rises naturally in the luteal phase. If you are post-menopausal, timing is less critical.

Collection in the morning is generally preferred, as 17-OHP follows a mild circadian pattern alongside cortisol.

After the test

Share your results with your GP or endocrinologist. A normal 17-OHP result on an early follicular morning sample makes CAH due to 21-hydroxylase deficiency unlikely. An elevated result will typically be followed by ACTH stimulation testing before a diagnosis is made.

If non-classical CAH is identified, your practitioner will discuss whether treatment is appropriate based on your symptoms and circumstances. For women with fertility concerns, a referral to a reproductive endocrinologist may be appropriate.

Your test results will be available in your private dashboard. If there are any urgent issues, we'll let you know so you can follow up with your health professional.

Understanding results

Results are reported in nanomoles per litre (nmol/L). Reference ranges are laboratory-specific and depend on sex, age, and for women, cycle phase. Your result report will include the applicable range.

A basal 17-OHP below the laboratory's reference range effectively excludes classical and most non-classical CAH due to 21-hydroxylase deficiency. A clearly elevated result is consistent with this diagnosis. Results that are borderline or mildly elevated, particularly in symptomatic patients, typically lead to an ACTH stimulation test, where 17-OHP is measured before and 60 minutes after a dose of synthetic ACTH. An exaggerated rise in 17-OHP after ACTH is consistent with adrenal enzyme deficiency.

In people with known CAH on treatment, 17-OHP is used to monitor whether their corticosteroid dose is adequate, aiming to keep levels within a target range that avoids both under- and over-treatment.

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Frequently bought together

Frequently Asked Questions

Most collection centres accept walk-ins. Some may require a booking - check details when you click on your chosen location.

If your test needs fasting, we’ll include that in your instructions after you order. Fasting usually means no food for 8–12 hours, but water is fine.

Just your pathology referral form (we email it to you)

Of course. Just maybe don’t bring the friend who faints at the sight of blood.

They’re the highly trained professionals who take your blood sample - with a steady hand and a sharp needle. They love blood, but don’t worry… they’re not vampires. Just legends who make blood tests quick, clean, and (almost) painless.

Some of our tests include Urine, Stool, Saliva and more. Each test will have a clear description on what sample you will need to give and instructions on how.