How to prepare
- No fasting is required for most caeruloplasmin measurements, though some laboratories may have specific requirements — check with your GP
- Caeruloplasmin is an acute-phase reactant, meaning it rises with inflammation, infection, pregnancy, and oestrogen use. Let your doctor know about any recent illness, pregnancy status, or oestrogen-containing medications
- Oral contraceptives significantly raise caeruloplasmin — this is important context for interpreting results in women
After the test
This test is almost always ordered as part of a specialist workup rather than as a standalone test. The results should be reviewed by the ordering doctor — typically a gastroenterologist, hepatologist, or neurologist when Wilson's disease is being investigated. If caeruloplasmin is low and Wilson's disease is possible, further tests including urine copper and liver assessment will typically follow.
Your test results will be available in your private dashboard. If there are any urgent issues, we'll let you know so you can follow up with your health professional.
Understanding results
The normal range for caeruloplasmin in adults is approximately 0.2–0.6 g/L. Low caeruloplasmin can indicate Wilson's disease, copper deficiency, severe liver disease (where the liver fails to produce it), or a rare inherited condition called aceruloplasminaemia. High caeruloplasmin is seen in pregnancy, oestrogen use, and inflammatory conditions. Caeruloplasmin should never be interpreted in isolation — your GP or a specialist will use it alongside serum copper, clinical findings, and other investigations.
