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Anti Streptococcal O Titre (ASOT) Blood Test

$44.00 AUD

Experiencing joint pain, skin rashes, or other unexplained symptoms weeks after a sore throat that your doctor wants to investigate?

Measures ASO antibodies produced in response to Group A Streptococcus infection. Used to investigate post-streptococcal complications such as rheumatic fever and glomerulonephritis, which can develop weeks after a strep throat or skin infection.

Collection Location
Specimen Type

You will be emailed a referral to take to your local collection centre. If you ever have any questions, we're here to help.

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1
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Order the private test that suits you and your goals. After ordering, you will receive your referral by email.

2
Collect the sample

Collect the sample

Attend one of our 4000+ partner collection centres throughout Australia. Search locations.

3
Receive your results

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View all your lab results in your secure health dashboard. Easy!

Overview

ASOT measures antibodies your immune system produces against streptolysin O, a toxin released by Group A Streptococcus during infection. This test may indicate recent strep exposure when investigating complications that develop weeks after the initial infection.

Rheumatic fever and post-streptococcal glomerulonephritis are conditions that can follow a strep infection. Both require documentation of preceding streptococcal infection as part of their diagnostic work-up, and ASOT is one of the key tests used in this process.

The test is most useful when symptoms appear one to five weeks after a sore throat and strep infection is suspected as the underlying trigger.

Symptoms

Used when investigating suspected rheumatic fever, post-streptococcal glomerulonephritis, or unexplained joint inflammation and other symptoms following a recent sore throat. Elevated ASOT levels may indicate recent Group A Streptococcus exposure.

Questions

  • An elevated ASOT suggests your immune system has recently responded to a Group A Streptococcus infection. It does not on its own indicate a specific disease. Your practitioner will interpret the result alongside your symptoms, examination findings, and other tests.
  • ASOT is most useful when investigating complications that appear one to five weeks after a sore throat or skin infection, including suspected rheumatic fever, post-streptococcal glomerulonephritis, or unexplained joint inflammation.
  • Generally above 200 IU/mL in adults suggests recent strep exposure, though reference ranges vary between laboratories. Rising titres on repeat testing two to four weeks apart are more clinically significant than a single elevated value.
  • Levels typically begin rising one to three weeks after infection, peak at three to five weeks, and gradually decline over six to twelve months. Some individuals carry mildly elevated baseline titres without active disease.
  • Combining both tests improves the chance of detecting a recent strep infection. ASOT responds strongly to throat infections, while Anti-DNase B is more sensitive to strep skin infections. Together they cover a broader range of streptococcal presentations.
  • The Jones criteria are a set of clinical guidelines used to support a diagnosis of rheumatic fever. They require evidence of a recent streptococcal infection (such as an elevated ASOT) plus specific combinations of major and minor clinical features including carditis, arthritis, and fever.

Dr. Vu Tran
Bloody Good’s Chief Medical Officer

No biomarkers found for this product.

How to prepare

No special preparation is required. Fasting is not necessary. You can eat and drink normally before your blood draw.

After the test

Take your result to your GP or requesting practitioner. If a post-streptococcal complication such as rheumatic fever is suspected, further investigation and specialist referral may follow. Your doctor may recommend serial testing (repeating the ASOT two to four weeks later) to look for a rising titre pattern. Combining ASOT with an Anti-DNase B test can improve the overall sensitivity for detecting recent strep infections, particularly those originating from skin rather than throat.

Your test results will be available in your private dashboard. If there are any urgent issues, we'll let you know so you can follow up with your health professional.

Understanding results

ASOT is reported in IU/mL. Levels above the reference range (generally above 200 IU/mL in adults, though this varies by laboratory) may suggest recent streptococcal infection. A single elevated reading does not on its own indicate disease. Rising titres on repeat testing two to four weeks apart are more clinically significant than a single value. Some people, particularly children, naturally carry higher baseline titres. Your practitioner will interpret your result alongside your symptoms and clinical history.

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Frequently Asked Questions

Most collection centres accept walk-ins. Some may require a booking - check details when you click on your chosen location.

If your test needs fasting, we’ll include that in your instructions after you order. Fasting usually means no food for 8–12 hours, but water is fine.

Just your pathology referral form (we email it to you)

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