Uric acid

Overview

Urate, also known as uric acid, is a chemical compound that is produced when the body breaks down purines, substances found in certain foods and tissues. It is a waste product that is normally excreted through the kidneys in urine. Urate levels in the blood can vary depending on factors such as diet, genetics, and how well the kidneys are functioning.

Testing Levels:

• High (0.45 mmol/L) - High levels of urate in the blood can lead to the formation of crystals, which can deposit in joints and cause gout, a type of arthritis characterized by sudden, severe episodes of joint pain, swelling, and redness. High urate levels may also be associated with certain medical conditions like kidney stones or kidney disease.
  
  
• Mid - Normal levels of urate in the blood typically indicate that the body's production and excretion of uric acid are balanced and within a healthy range. Normal urate levels suggest that the kidneys are functioning well to eliminate uric acid, and there is no excess buildup that could lead to conditions like gout or kidney stones.
  
  
• Low (0.2 mmol/L) - Low levels of uric acid in the blood can mean a few different things. It might indicate problems with the liver, like severe liver disease, or rare conditions like Wilson's disease, which affects how the body handles copper. Poor diet or issues with absorbing nutrients in the gut can also lead to low uric acid. Certain medications and chronic lead poisoning can also bring down uric acid levels.

Why We Test Uric acid

What Affects It

Several factors influence uric acid levels in the body. Diet plays a significant role, as foods high in purines - such as red meat, organ meats, certain seafood, and alcohol - can increase uric acid production. Genetic factors also play a part, influencing how the body processes and excretes uric acid, potentially leading to elevated levels in some individuals. Kidney function is critical, as impaired kidney function can reduce uric acid excretion, resulting in higher levels in the blood. Medications like diuretics, low-dose aspirin, and certain immunosuppressive drugs can affect uric acid levels by either reducing excretion or increasing production. Various health conditions, including those involving increased cell turnover or metabolic disorders like obesity and insulin resistance, can also contribute to elevated uric acid levels. Additionally, dehydration can concentrate uric acid in the blood, further influencing its levels. Understanding and managing these factors are crucial for individuals at risk of conditions like gout and kidney stones associated with high uric acid levels.

How to Improve

Common Name: Uric Acid