Adrenocorticotropic Hormone

ACTH is a hormone produced by the pituitary gland that regulates cortisol production by the adrenal glands, playing a crucial role in stress response and maintaining metabolic balance.

📋 About This Biomarker

ACTH is a critical hormone produced by the pituitary gland, which is often called the "master gland" because it regulates various other glands in the body. ACTH stimulates the adrenal glands, located on top of the kidneys, to produce cortisol. Cortisol is essential for the body’s response to stress, regulating metabolism, and maintaining blood pressure. Think of ACTH as the signalman on a railway, directing the adrenal glands when to release cortisol to keep the body’s “trains” running smoothly. If cortisol levels are too low, ACTH production ramps up to stimulate the adrenals to produce more; if cortisol is too high, ACTH production decreases, creating a feedback loop that keeps the system balanced. Monitoring ACTH provides insights into how well this system is functioning and can reveal disruptions in this hormonal balance.

🎯 Why We Test This

Testing ACTH levels is important for understanding the health of the pituitary and adrenal glands, especially in diagnosing conditions like Addison’s disease, Cushing’s syndrome, or pituitary disorders. By examining ACTH levels, healthcare providers can assess how well the body is managing stress and whether the hormonal balance is maintained. It’s a key diagnostic tool for anyone experiencing symptoms related to stress, energy levels, or unexplained weight changes, and for those with conditions that may affect adrenal or pituitary function.

⚠️ What Affects It

ACTH levels can be influenced by a variety of factors, including the time of day, stress levels, and medical conditions affecting the adrenal or pituitary glands. For example, ACTH typically peaks in the early morning and falls throughout the day, following a circadian rhythm. Physical and emotional stress can also spike ACTH levels as the body prepares to manage the stressor. Conditions such as Addison’s disease (where the adrenal glands don’t produce enough cortisol) can cause elevated ACTH levels, as the pituitary tries to compensate. Conversely, Cushing’s syndrome, where there is too much cortisol, can suppress ACTH levels. Understanding these influences is key to accurately interpreting ACTH results.

📈 How to Improve

Managing ACTH levels depends on addressing the root cause of any imbalance. For high ACTH levels, stress management techniques, treating underlying conditions like Addison’s disease, or addressing ectopic ACTH production can help bring levels down. If ACTH is close to the upper limit, lifestyle changes, such as reducing stress and ensuring good sleep hygiene, can prevent further elevation.

For low ACTH levels, treatment may focus on addressing the underlying pituitary disorder or adjusting medications that might suppress ACTH production. In cases where ACTH is close to the lower limit, careful monitoring and possible adjustments to medication or lifestyle may be needed to prevent further decline. Regular consultation with a healthcare provider and ongoing monitoring are key to keeping ACTH within a healthy range.

📊 Understanding Your Results (pmol/L)

Low (< 2 pmol/L)
Low ACTH levels can be a sign that the pituitary gland is not producing enough ACTH, leading to insufficient stimulation of the adrenal glands. This is often seen in secondary adrenal insufficiency, where a pituitary problem causes a drop in ACTH production, leading to low cortisol levels. Symptoms might include fatigue, muscle weakness, and weight gain due to a sluggish adrenal response. This scenario is like a factory slowing down production because the orders from the control centre have decreased. Addressing the underlying issue, possibly with hormone replacement or treating a pituitary condition, is essential.
Optimal (2 - 11 pmol/L)
ACTH levels within the reference range suggest that the pituitary and adrenal glands are communicating well and that cortisol production is in balance. This indicates a healthy response to stress and a well-regulated metabolic system. It’s like the body’s control system is running smoothly, with all parts working in harmony, ensuring that cortisol is produced just when it’s needed and in the right amounts. When ACTH levels are near the upper limit, it might indicate the body is beginning to experience stress or the adrenal glands are starting to underperform, but not to a degree that causes overt symptoms. This is like seeing the first signs of wear in a machine that’s been working hard - it’s functioning, but the strain is starting to show. Close monitoring and early intervention, such as stress management or medical evaluation, might prevent progression to more serious conditions. When ACTH levels are close to the lower limit, it may indicate that the pituitary gland is reducing its signal to the adrenal glands, possibly because there is already sufficient cortisol in the system. This could be due to external factors like prolonged use of corticosteroid medications or could hint at an early stage of Cushing’s syndrome. It’s akin to seeing the warning light on a dashboard flicker - you’re not in trouble yet, but something might need attention.
High (> 11 pmol/L)
Elevated ACTH levels typically indicate an issue with the adrenal glands or a condition where the body is under increased stress. High ACTH may suggest adrenal insufficiency, like Addison’s disease, where the adrenal glands are underactive and unable to produce adequate cortisol. The pituitary gland compensates by producing more ACTH, attempting to “nudge” the adrenal glands into action. It could also point to ectopic ACTH production, often due to certain tumours. Symptoms associated with high ACTH can include fatigue, weight loss, and darkened skin due to overstimulation of the adrenal glands.
Also known as: ACTH, ADRENOCORTICOTROPHIC HORMONE