Hormone & Endocrine - Bloody Good
Hormone

Oestradiol (E2)

Wondering about your hormone balance? Oestradiol (E2) is the main form of oestrogen and plays a key role in fertility, menstrual cycles, bone strength, and overall hormone health. This test may help assess fertility, menopause status, or hormone-related symptoms in both women and men.

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Oestradiol (E2)

Wondering if hormonal changes, menstrual irregularities, menopausal symptoms, or concerns about bone and heart health could be linked to your oestradiol levels?

Overview

Oestradiol is your body's most powerful form of estrogen, working like a master conductor that coordinates essential functions throughout your entire system. While it's best known for regulating women's menstrual cycles and supporting reproductive health, this versatile hormone actually acts as your body's multi-talented assistant, helping maintain strong bones by boosting calcium absorption, supporting heart health through healthy cholesterol levels, and even influencing your mood, memory, and skin elasticity.

Testing your oestradiol levels gives you valuable insight into how well this crucial hormone is performing its many jobs. When levels are too high or too low, you might experience symptoms like irregular periods, mood changes, bone weakness, or menopausal effects like hot flashes. Since oestradiol naturally fluctuates throughout your menstrual cycle, during pregnancy, and especially during menopause, understanding your current levels helps explain what's happening in your body and guides decisions about your health and wellbeing. Even men produce small amounts of oestradiol for bone and brain health, making this test relevant for everyone seeking to understand their hormonal balance.

Reviewed by Dr. Vu Tran
Bloody Good’s Chief Medical Officer

Symptoms

You may benefit from this test if you experience:
Irregular periods (cycles shorter than 21 or longer than 35 days) Missed periods (not due to pregnancy) Hot flashes during the day Night sweats that wake you up Low sex drive in women Vaginal dryness Difficulty getting pregnant Very light menstrual periods Sudden feeling of heat and sweating Painful intercourse Breast size changes Enlarged breasts in men Night sweats not related to menopause

Purpose

Essential for women experiencing irregular periods, fertility issues, or menopausal symptoms. Important for monitoring hormone replacement therapy effectiveness. Valuable for assessing bone health risk, investigating unexplained osteoporosis, and evaluating cardiovascular risk factors in both men and women.

How to prepare

Timing is important for menstruating women. For cycle assessment, test on day 21 of a 28-day cycle or 7 days after suspected ovulation. For fertility evaluation, multiple tests throughout the cycle may be needed. No fasting required. Inform your healthcare provider about hormone medications, birth control, or supplements as these can significantly affect results.

Understanding results

Normal ranges vary by gender, age, and cycle phase. Pre-menopausal women (follicular): 50-200 pmol/L; Pre-menopausal women (luteal): 300-750 pmol/L; Post-menopausal women: <150 pmol/L; Men: 50-200 pmol/L. Low levels may indicate ovarian dysfunction, menopause, or eating disorders. High levels might suggest ovarian cysts, liver disease, or hormone therapy effects.

After the test

Discuss results with a healthcare provider experienced in hormone management. Low oestradiol may require hormone replacement therapy, lifestyle modifications, or treatment of underlying conditions. High levels might need investigation for ovarian cysts, liver function, or medication adjustments. Bone density screening may be recommended for low oestradiol levels.

Frequently Asked Questions

  • Oestradiol (E2) is the most potent oestrogen, primarily produced by ovaries. Oestrone (E1) is weaker and more prevalent after menopause, while oestriol (E3) is mainly produced during pregnancy. Oestradiol is most clinically relevant.
  • Oestradiol levels gradually decline during perimenopause, then drop dramatically after menopause to less than 20% of pre-menopausal levels. This decline is responsible for most menopausal symptoms.
  • Yes, oestradiol monitoring is crucial during fertility treatments to assess ovarian response to medications, time egg retrieval, and evaluate endometrial development for embryo transfer timing.
  • Low oestradiol in reproductive-age women may indicate premature ovarian insufficiency, excessive exercise, eating disorders, stress, or pituitary problems. Further evaluation is usually needed.
  • Oestradiol stimulates bone formation and reduces bone breakdown. Low levels, especially after menopause, significantly increase osteoporosis risk. Hormone replacement therapy can help protect bones.
  • Yes, men need small amounts of oestradiol for bone and brain health. Too little can cause bone loss and cognitive issues, while too much might indicate liver problems or certain medications.
Oestradiol (E2)

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