Autoimmune - Bloody Good
Thyroid

Thyroglobulin

The Thyroglobulin Test measures a protein made by the thyroid gland. After thyroid surgery or treatment for thyroid cancer, this test may help check for recurrence. It can also be used alongside antibody tests to assess thyroid function and possible autoimmune activity.

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Thyroglobulin

Have thyroid cancer history, previous thyroid surgery, or abnormal thyroid function and need assessment of thyroid tissue activity for ongoing monitoring?

Overview

The Thyroglobulin test measures a special protein that acts like your thyroid's unique fingerprint—it's only made by thyroid tissue, nowhere else in your body. Think of thyroglobulin as your thyroid's storage container for thyroid hormones, quietly doing its job in the background and releasing tiny amounts into your bloodstream during normal function. This test works by checking how much of this protein is circulating in your blood, giving doctors valuable insight into what your thyroid tissue is up to.

This test is especially important for people who've had thyroid cancer, as it serves as an early warning system to detect if cancer cells are trying to make a comeback. When thyroglobulin levels are higher than expected, it could signal increased thyroid activity, various thyroid disorders, or in cancer survivors, the possibility that some thyroid tissue or cancer cells remain active. For anyone monitoring thyroid health—whether you've had thyroid surgery, are dealing with thyroid nodules, or have a family history of thyroid problems—this test helps your healthcare team stay one step ahead, ensuring treatments are working effectively and catching any changes before they become bigger concerns.

Reviewed by Dr. Vu Tran
Bloody Good’s Chief Medical Officer

Symptoms

You may benefit from this test if you experience:
Enlarged thyroid gland or goiter Feeling tired all the time Always feeling cold even in warm weather Family history of thyroid cancer Age-appropriate cancer screening Difficulty swallowing solids Feeling like something is stuck in throat

Purpose

Essential for individuals with thyroid cancer history, post-thyroid surgery, thyroid disorders, or anyone needing comprehensive thyroid tissue and cancer monitoring assessment.

How to prepare

No special preparation required. Inform healthcare provider of thyroid medications, recent thyroid procedures, and any factors that might affect thyroglobulin levels or interpretation.

Understanding results

Results show thyroglobulin levels compared to normal ranges. Elevated levels may indicate thyroid tissue activity, cancer recurrence, or thyroid disorders requiring further evaluation.

After the test

Address abnormal thyroglobulin through thyroid cancer surveillance, additional imaging studies, treatment adjustments, and specialized thyroid cancer care. Work with oncologists and endocrinologists for cancer monitoring.

Frequently Asked Questions

  • Thyroglobulin is a protein made only by thyroid tissue; it serves as a tumor marker for thyroid cancer monitoring and assessment of thyroid tissue activity.
  • Elevated levels may indicate thyroid tissue activity, thyroid disorders, or in thyroid cancer patients, potential cancer recurrence requiring further evaluation.
  • Testing is primarily used for thyroid cancer patients to monitor treatment effectiveness and detect recurrence, and for evaluating certain thyroid disorders.
  • For thyroid cancer patients, testing frequency depends on cancer stage and treatment, typically every 6-12 months initially, then annually if stable.
  • Levels can be affected by thyroid tissue presence, thyroid medications, recent procedures, and thyroid antibodies that may interfere with testing.
  • Very low or undetectable levels are expected after complete thyroid removal and successful cancer treatment, indicating no residual thyroid tissue.
Thyroglobulin

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What to expect

We want you to feel bloody good—inside and out. Regular testing isn’t just about checking your current health; it helps you spot abnormal values you might not know about.

1

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2

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3
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